FORMULASI SEDIAAN KRIM EKSTRAK ETANOL KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) DAN UJI AKTIVITAS TERHADAP BAKTERI (STAPHYLOCOCCUS AUREUS)

  • Iffa Khoirunisa
  • Eni Masruriati
  • Wicaksono Wicaksono
DOI: https://doi.org/10.32583/farmasetis.v7i2.392

Abstract

ABSTRAK

Kulit buah naga mengandung vitamin C, vitamin E, vitamin A, alkaloid, terpenoid, flavonoid, tiamin, niasin, piridoksin, kobalamin, fenolik, karoten, dan fitoalbumin. Aktivitas antibakteri ekstrak etanol 60% dan ekstrak air kulit buah naga merah terhadap bakteri Staphylococcus aureus dan eschericia coli dengan konsentrasi 73, 36, 18 mg/L mampu menghambat bakteri Staphylococcus aureus dan Eschericia coli. Uji aktivitas bakteri pada krim ekstrak etanol kulit buah naga merah dilakukan dengan metode difusi cakram. Uji dengan ekstrak etanol 70% kulit buah naga merah yang dicampurkan basis krim 3 konsentrasi ekstrak yang berbeda, yaitu F1 F2 F3 (konsentrasi ekstrak20%, 30%,40%,kontrol positif dan kontrol negatif. Kesimpulan: krim ekstrak kuli buah naga merah mampu menghambat bakteri Staphylococcus aureus. F3 paling efektif menghambat pertumbuhan 

Keywords: Kulit buah naga merah, antibakteri, formulasi krim, Staphylococcus aureus

 

SUPPLY FORMULATION CREAM ETHANOL EXTRACTS OF RED DRAGON LEATHER (HYLOCEREUS POLYRHIZUS) AND TEST ACTIVITIES TOWARDS BACTERIA (STAPHYLOCOCCUS AUREUS)

 

ABSTRACT

Dragon fruit skin contains vitamin C, vitamin E, vitamin A, alkaloids, terpenoids, flavonoids, thiamine, niacin, pyridoxine, cobalamin, phenolic, carotene, and phytoalbumin. Antibacterial activity of 60% ethanol extract and red dragon fruit skin water extract against Staphylococcus aureus and Escherichia coli with concentrations of 73, 36, 18 mg / L were able to inhibit Staphylococcus aureus and Eschericia coli bacteria. The bacterial activity test on red dragon fruit skin ethanol extract cream was carried out by disc diffusion method. Test with 70% ethanol extract red dragon fruit skin mixed with cream base 3 different extract concentrations, namely F1 F2 F3 (extract concentration 20%, 30%, 40%, positive control and negative control. Conclusion: red dragon fruit coolies extract cream is able inhibits Staphylococcus aureus bacteria, the most effective F3 inhibits growth. Keywords: Red dragon fruit skin, antibacterial, cream formulation, Staphylococcus aureus