FAKTOR RISIKO INTERNAL TERHADAP KEJADIAN GAGAL KONVERSI PENGOBATAN PENDERITA BARU TUBERKULOSIS PARU FASE INTENSIF

  • Olys Olys
  • Ferry Ardhiansyah
DOI: https://doi.org/10.32583/farmasetis.v7i1.303

Abstract

ABSTRAK

Tuberkulosis bersama HIV kini menjadi penyebab utama kematian diseluruh dunia. Secara global pada 2014 terdapat 9,6 juta orang diperkirakan menderita TB. Capaian angka konversi TB di Provinsi Lampung berdasarkan Riskesdas 2010 dan 2013 mengalami penurunan yang cukup tajam yaitu 90% pada 2011 menjadi hanya 38,1% pada 2014 (target Nasional >85%). Faktor internal berkaitan erat dengan kejadian tersebut, maka perlu dilakukan kajian mendalam untuk mengetahui faktor risiko internal yang mempengaruhi kegagalan konversi penderita TB pada pengobatan fase intensif. Penelitian ini merupakan penelitian observasional analitik dengan desain Kohort. Populasi studi adalah penderita TB paru di Kota Bandar Lampung yang baru memulai pengobatan. Sampel berjumlah 126, variabel dependen adalah kejadian gagal konversi, variabel independen yaitu faktor internal ( kadar Haemoglobin, merokok dan konsumsi alkohol). Sampel diperoleh secara exhaustive sampling. Hasil penelitian ini adalah ada hubungan konsumsi minuman beralkohol (aRR=5,5; CI 95% : 1,927-15,566; p=0,001) dengan kejadian kegagalan konversi. Variabel yang tidak berhubungan dengan kegagalan konversi adalah merokok (aRR=0,7; CI95% : 0,237-2,334; p=0,611) dan Kadar Haemoglobin (aRR=0,6 CI 95% : 0,124-2,977; p=0,540). Konsumsi minuman beralkohol pada penderita TB berpengaruh terhadap gagal konversi pengobatan penderita baru tuberkulosis paru fase intensif.

 

Kata kunci : Tuberkulosis Paru, Konsumsi Minuman Beralkohol, Kegagalan Konversi.

 

 

THE INTERNAL FACTORS THAT INFLUENCE THE CONVERSION FAILURE OF TB PATIENTS IN THE INTENSIVE PHASE OF TREATMENT

 

ABSTRACT

Tuberculosis along with HIV is a major cause of death worldwide. Globally in 2014, there were an estimated 9.6 million people get TB. Achievement conversion rate of TB in the province of Lampung based Riskesdas 2010 and 2013 experienced a sharp decline of 90% in 2011 to only 38.1% in 2014 (National target> 85%). Internal factors are closely related to the incident, it is necessary to do in-depth study to determine the internal factors that influence the conversion failure of TB patients in the intensive phase of treatment. This research was analytic observational cohort design. The study population was patients with pulmonary tuberculosis in the city of Bandar Lampung starting treatment. The total sample of 126, the dependent variable was the incidence of failed conversion, independent variables are internal factors (hemoglobin levels, smoking and alcohol consumption). Samples were obtained by exhaustive sampling. Result of consumtion alcoholic beverages (aRR= 5,5; 95%CI : 1,927 to 15,566; p=0,001) proved to be a risk factor for conversion failure. Variables that are not proven statistically are risk factors of conversion failure, are smoking (aRR = 0,7, CI95%: 0,237-2,334; p = 0,611), and Haemoglobin level (aRR = 0,6 CI 95%: 0,124-2,977; p = 0,540). Consumtion alcoholic beverages in tuberculosis patients effect on conversion failure of TB patients in the intensive phase of treatment.

 

Keywords:  Pulmonary Tuberkulosis, Consumtion Alcoholic Beverages, Conversion Failure