Uji Aktivitas Anti Obesitas Kombinasi Infusa Rimpang Bengle dan Biji Kopi Hijau
Abstract
Obesitas merupakan penyakit metabolic yang paling umum dan terkait dengan penyakit kronis, sehingga perlu perhatian khusus. Penelitian ini bertujuan untuk mengamati mekanisme aktivitas anti obesitas dari kombinasi Infusa Bengle (Zingiber cassumunar Roxb.) dan Kopi Hijau (Coffea arabica L.). Penelitian dilakukan dengan memberikan infusa bengle dan kopi hijau pada mencit jantan, aktivitas yang diberikan dilihat dari berat badan mencit, berat feses dan berat pakan perhari. Berat badan mencit diukur perhari dan diperoleh data kontrol negatif 23.12g ± 2.29g ; kontrol sehat 22.32g ± 0.97g; Dosis 1, 2 dan 3 secara berturut-turut 22.8g ±1.64g; 22.45g ± 1.21g; dan 20.57g ±0.57g. Berat feses perhari diperoleh data kontrol negatif 755.27mg ± 207.18mg; kontrol sehat 632.00mg ± 69.75mg; Dosis 1, 2 dan 3 secara berturut-turut 874.76mg ± 201.18mg; 809.26mg ± 180.16mg dan 678.16mg ± 221.46mg. Berat pakan diukur perhari diperoleh data kontrol negatif 3.39g ± 1.07g; kontrol sehat 2.59g ± 0.84g; Dosis 1, 2 dan 3 secara berturut-turut 3.04g ± 0.67g; 2.67g ± 0.52g dan 2.2g ± 0.82g. Hasil menunjukan aktivitas penurunan berat badan dan berat pakan secara signifikan (p<0,05) sedangkan berat feses menunjukan hasil tidak bermakna (p>0,05). Dosis 3 menunjukan hasil terbaik untuk penurunan berat badan dan berat pakan disbanding dosis 1, dosis 2 dan kontrol sehat.
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