Jurnal Farmasetis http://journal.stikeskendal.ac.id/index.php/far <p>Penulis jurnal berasal dari tenaga kesehatan, dosen, mahasiswa, peneliti yang tertarik dalam bidang farmasi. Jurnal diterbitkan pertama kali sejak Juni&nbsp; tahun 2011, dan &nbsp;terbit dengan&nbsp; &nbsp;ISSN versi cetak pada Volume 2 No 1 Juni 2012 dan ISSN versi online pada Volume 6 No 1 Mei 2017. Jurnal farmasetis terbit 2 kali dalam setahun yaitu bulan Mei dan November.</p> LPPM STIKES KENDAL en-US Jurnal Farmasetis 2252-9721 Uji Pendahuluan Kitosan Cangkang Kerang Batik http://journal.stikeskendal.ac.id/index.php/far/article/view/751 <p><em>Chitosan is a polysaccharide compound produced by deacetylation of chitin shells in batik shells. Batik shells in Kendal are often found in the waters of Rowosari Kendal. the many benefits of chitosan, such as natural food preservatives, are the basis for further research derived from of batik shells.The one of benefit ingredients of batik shells is chitin and chitosan. The purpose of this study is to preliminary test batik shells is chitin and chitosan. This method is experimental with a population of all batik shells in Rowosari Kendal</em><em>, </em><em>a sample of in part of the batik shells with the criteria obtained from Rowosari, Kendal. This research was conducted in the Kendal STIKES laboratory. Experiments with repeated on average experiments 5 times later. The research treatment is the post test only design which is divided into 3 groups. The test group was given chitosan batik shells with concentrations of 25%, 50% and 75%.</em> <em>The results were then analyzed using univariate statistical analysis in the form of an average of chitin yield, an average of chitosan yield and a standard deviation. This result preliminary test in this study indicate the presence of chitosan compounds. The average yield of chitin shells is 89.88 ± 0.022, while the average yield of chitosan shells of batik shells is highest at a concentration of 75% w / v of 7.53% w / v.</em></p> Ariyanti Ariyanti Eni Masruriati Alfenila Alfenila ##submission.copyrightStatement## 2020-05-21 2020-05-21 9 1 1 6 10.32583/farmasetis.v9i1.751 Uji Stabilitas Fisik Krim Ekstrak Etanol Temulawak dengan Perbedaan Konsentrasi Asam Stearat http://journal.stikeskendal.ac.id/index.php/far/article/view/767 <p><em>Temulawak extract or </em><em>C</em><em>urcuma </em><em>x</em><em>anthorrhiza </em>Roxb<em> was obtained by extracting the plant using the maceration method. The extract is formulated into an oil-type oil in water (M / A). The use of different stearic acid concentration aims to know the difference of physical stability of tart cream ethanol extract. Physical stability testing is done at room temperature 20-30<sup>0</sup>C after one month, then performed physical stability test include organoleptis, homogeneity, spreading, stickiness and protection time.The cream of temulawak ethanol extract showed homogeneous results for all formulas. Organoleptic observations showed no change in color and odor but there was a change in consistency after one month storage at room temperature 20-30<sup>0</sup>C. In the sticky strength test the creams occur instability due to the decreased sticking power of the cream for all formulas. The result of spreading test showed the instability indicated by the increasing ability of spreading cream after one month storage at room temperature 20-30<sup>0</sup>C for all formula. Result of protection test of cream of temulawak extract good day-0 and day-30 red stain rather disappeared on filter paper that depleted KOH.</em></p> Devi Septiana Eni Masruriati Nita Fajaryanti ##submission.copyrightStatement## 2020-05-21 2020-05-21 9 1 7 14 10.32583/farmasetis.v9i1.767 Pengaruh Perbedaan Kondisi Tanah Tumbuhan Ciplukan pada Morfologi, Anatomi dan Metabolit Sekunder http://journal.stikeskendal.ac.id/index.php/far/article/view/707 <p><em>Physalis angulata </em>L<em> is a herbal plant that has many benefits empirically as a drug of diarrhea, diabetes, hives and so on. It usually grows in tropical and subtropical areas. Factors affecting plant life are soil conditions, altitude and temperature. The purpose of this research is to determine the effect of differences in plant soil conditions on morphology, anatomy, and secondary metabolites of the captured.&nbsp; The research methods include identifying morphology, anatomical identification, and screening phytochemicals secondary metabolites. The results showed that morphology of the (Riau) province has a color of yellowish green leaves while the skin (Jambi) color is dark green leaves. The fruit petals of the Physalis angulata (Riau) are purplish while the shell (Jambi) is green. In anatomical examination (leaf) both have epidermis, palisade tissue, conveyance and stomata, (STEM) both have epidermis tissue, base tissue, tissue amplifier, (root) both have epidermis, cortex, and carrier tissue. The secondary metabolite of the plant contains alkaloids, flavonoids, saponins, triterpenoids, polyphenols (leaves) alkaloids, flavonoids, saponins, triterpenoids, quinone, polyphenols (stems), triterpenoids, quinone (roots). So there was a difference between the cipering (Riau) and the shell (Jambi) that was from the color of the leaf, the height of the stem, and the color of the petals on the fruit while the other is the same In terms of anatomical structure and secondary metabolite in the Physalis angulata (Riau) and the Physalis angulata (Jambi) has no specific differences.</em></p> Lili Andriani Santi Perawati Zaitun Zaitun ##submission.copyrightStatement## 2020-05-25 2020-05-25 9 1 15 22 10.32583/farmasetis.v9i1.707 Evaluasi Penggunaan Antibiotik pada Pasien Anak dengan Diare http://journal.stikeskendal.ac.id/index.php/far/article/view/730 <p><em>Diarrhea is a major cause of child illness and death in the world and is the second leading cause of death after pneumonia in children under five years. Diarrhea can affect all age groups, especially in infants and children. Diarrhea can be caused by viral, bacterial and parasitic infections. This study aims to determine the suitability of antibiotic use therapy in pediatric patients diagnosed with diarrhea at the Inpatient Clinic of the Pratama Bina Husada I Cilacap. Research was conducted observationally non-experimental by collecting data taken retrospectively with a total sample of 38 patients. The sample in this study were children aged 2-12 years diagnosed with diarrhea with frequency of defecation more than 3 times a day, patients who received antibiotic therapy and underwent hospitalization and had complete medical record data. Data were collected and analyzed including the exact patient, exact medication, right dose and exact administration.The results showed that 100% of patients were right, 100% precise indication, 94.72% correct drug and the right dose included the accuracy of the dose amount of 92.10%, the accuracy of the frequency of administration could not be known because the guidelines did not specify the frequency of administration, the exact duration of administration 71, 05% and route of giving 94.72%.</em></p> Tinuk Susanti Supriani Supriani ##submission.copyrightStatement## 2020-05-25 2020-05-25 9 1 23 30 10.32583/farmasetis.v9i1.730 Standardisasi Simplisia Daun Ciplukan http://journal.stikeskendal.ac.id/index.php/far/article/view/736 <p><em>Leaves ciplukan Physalis angulata L. is often utilized by people because it has many benefits as a traditional medicine standardization that needs to be done to get a good simplicia. Penetapkan standard parameters ciplukan leaf botanicals that include non-specific parameters and specific parameters taken from the Jambi to circumstances where grown black sandy soil and Riau area with clay soil conditions to grow black spot. Organoleptic form of powder, aromatic odor / typical, bitter taste, but memiliiki sample the color difference is a brownish green Jambi, Riau sample brownish-green. Levels of water-soluble compounds, sample Jambi Riau 20.65% and 22.01%, solute ethanol, 19.42% of samples Jambi and Riau sample of 19%. Simplicia leaves Jambi and Riau ciplukan samples containing alkaloids, steroids, flavonoids and saponins. The water content of the sample Jambi Riau 9.12% and 9.24%.Sample drying shrinkage Jambi Riau 9.38% and 9.76%.The ash content of 13.5% of the total sample Jambi and Riau 13.6%. Acid insoluble ash content samples Riau Jambi 2% and 2.1%. Metal contamination of lead (Pb) samples Jambi 0.0530 mg / g and Riau 0.07795 mg / g. So the test-specific and non-specific parameters simplisia sample Jambi and Riau region meet Indonesian Herbal Pharmacopoeia standards.</em></p> Ardi Wijanarko Santi Perawati Lili Andriani ##submission.copyrightStatement## 2020-05-25 2020-05-25 9 1 31 40 10.32583/farmasetis.v9i1.736 Pengaruh Lama Penggunaan Rokok Elektronik terhadap Kadar Karboksihemoglobin pada Perokok Elektronik http://journal.stikeskendal.ac.id/index.php/far/article/view/777 <p><em>Carbon monoxide (Co) has no taste, no colour, and no odor, but when it reach higher </em><em>concentration on the blood stream, it leads to sudden death. It can be obtained from cigarretes smoke. When it is inhaled, the affinity of hemoglobin for Co is greater than oxygen (O<sub>2</sub>).</em> <em>This will increase levels of carboxyhemoglobin (CoHb).The high CoHb concentration will cause many health problems such as cancer and cardiovascular disease.</em> <em>Cigarettes comsumtion in Indonesia is increasing rapidly every year, it includes electronic cigarettes (e-cigarettes).</em> <em>E-cigarettes </em><em>are commonly used in attempts to replace tobacco cigarettes because it’s less chemical compounds. But the recent researches show that e-cigarettes still contain some dangerous chemical compounds, on of them is Co. </em><em>This study aims to determine the effect of the smoking duration with e-cigarretes on CoHb concentrations in e-cigarettes smokers on Serengan Subdistrict in Surakarta. This was an experimental research with purposive sampling method. The concentrations of carboxyhaemoglobin was analyzed using UV-Vis Spectrophotometer. The test results were obtained concentrations of CoHb : 5.87%, 6.01%, 5.97%, 5.91%, 6.04%, 5.99%, 5.76%, 5.82%. from 8 respondents. The data was analyzed by linier regression and one-way anova test using SPSS.&nbsp; The conclusion is 81,90 % carboxyhaemoglobin concentrations is affected from the smoking duration and 18,10 % affected with other factors.</em></p> Wimpy Wimpy Tri Harningsih ##submission.copyrightStatement## 2020-05-25 2020-05-25 9 1 41 50 10.32583/farmasetis.v1i1.777