Meta Analisis Risk Ratio dan Hazard Ratio Kematian ODHA yang Terinfeksi Covid-19
Abstract
Patogenisitas COVID-19 bisa dipercepat pada orang yang hidup dengan HIV. Bukti terbaru telah menunjukkan substansial hubungan antara infeksi saluran pernapasan bawah terkait Coronavirus (Lower Respiratory Tract Infections (LRTI) dan peningkatan risiko kematian pada individu dengan gangguan kekebalan termasuk orang dengan HIV/AIDS. Meta analisis ini dibuat untuk mengestimasi risiko kematian orang dengan HIV/AIDS (ODHA) yang terinfeksi COVID-19 berdasarkan bukti yang dilaporkan dari berbagai belahan dunia. Pelaporan meta analisis ini dilakukan berdasarkan PRISMA. Pencarian basis data dilakukan Januari - Mei 2021, sepuluh dari 2062 artikel masuk ke dalam analisis RevMan menggunakan risk ratio dan hazard ratio. Hasil risk ratio (RR) pasien COVID-19 yang menderita HIV untuk meninggal dunia adalah 4.32 [95% CI (1.24, 15.05)]; p-value 0.002, sedangkan hazard ratio (HR) 10.36 [95% CI (7.11, 15.11)]; p-value <0,001. ODHA yang terinfeksi COVID-19 memiliki risiko untuk mengalami kematian berkisar antara 4 hingga 10 kali dibandingkan pasien COVID-19 tanpa HIV/AIDS. Kematian sebagian besar disebabkan oleh perburukan COVID-19 dengan koinfeksi HIV/AIDS seperti tuberculosis, hipertensi, diabetes, dan chronic obstructive pulmonary disease.
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