Efek Penggunaan Chlorhexidine dalam Menurunkan Jumlah Bakteri pada Ulkus Kaki Dibetik: A Literature Review
Keywords:
bakteri, klorheksidin, pasien DFU, ulkus kaki diabetik
Abstract
Ulkus kaki diabetik merupakan komplikasi kronis dan penyebab utama amputasi, umumnya dapat dicegah dengan penanganan yang tepat. Salah satunya penatalaksanaan perawatan luka dengan menggunakan antiseptik. Klorheksidin mengandung antiseptik yang berperan penting dalam mengurangi jumlah bakteri pada ulkus kaki diabetikum. Ulasan ini bertujuan untuk mengidentifikasi efektivitas penggunaan Chlorhexidine untuk menurunkan jumlah bakteri pada ulkus kaki diabetik. Desain yang digunakan dalam studi pustaka ini adalah tinjauan pustaka. Pencarian artikel menggunakan lima database yaitu PubMed, Ebscohost, Chocrane Library, dan Science Direct menggunakan kata kunci PICO. Ditemukan 1.032 artikel dalam periode 2010-2020. Penapisan dilakukan dengan menghapus artikel yang tidak sesuai dengan kriteria inklusi, dan ditemukan empat artikel yang sesuai dengan kriteria inklusi. Teridentifikasi 1.032 artikel dari tahun 2010-2020 dan lima artikel yang memenuhi kriteria inklusi. Beberapa hasil menunjukkan penggunaan Chlorhexidine efektif dalam mengurangi jumlah bakteri, serta membantu penyembuhan luka pada ulkus kaki diabetik. Klorheksidin merupakan terapi topikal yang efektif dalam perawatan luka karena Klorheksidin dapat menurunkan jumlah bakteri pada ulkus kaki diabetik dan dapat mempercepat penyembuhan ulkus kaki diabetik.
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Touzel, R. E., Sutton, J. M., & Wand, M. E. (2016). Establishment of a multi-species biofilm model to evaluate chlorhexidine efficacy. Journal of Hospital Infection, 92(2), 154–160. https://doi.org/10.1016/j.jhin.2015.09.013
Vali, L., Dashti, A. A., El-Shazly, S., & Jadaon, M. M. (2015). Klebsiella oxytoca with reduced sensitivity to chlorhexidine isolated from a diabetic foot ulcer. International Journal of Infectious Diseases, 34, 112–116. https://doi.org/10.1016/j.ijid.2015.03.021
Yu, J. J., Manus, M. B., Mueller, O., Windsor, S. C., Horvath, J. E., & Nunn, C. L. (2018). Antibacterial soap use impacts skin microbial communities in rural Madagascar. PLoS ONE, 13(8), 1–14. https://doi.org/10.1371/journal.pone.0199899
Yunding, M. (2019). efektifitas sabun antibakteri terhadap penurunan biofilem, koloni bakteri dan proses penyembuhan luka kaki diabetik: randomized clinical rtial.
Yusuf, S., Okuwa, M., Irwan, M., Rassa, S., Laitung, B., Thalib, A., … Sugama, J. (2016). Prevalence and Risk Factor of Diabetic Foot Ulcers in a Regional Hospital, Eastern Indonesia. Open Journal of Nursing, 06(01), 1–10. https://doi.org/10.4236/ojn.2016.61001
Banu, A., Noorul Hassan, M. M., Rajkumar, J., & Srinivasa, S. (2015). Spectrum of bacteria associated with diabetic foot ulcer and biofilm formation: A prospective study. Australasian Medical Journal, 8(9), 280–285. https://doi.org/10.4066/AMJ.2015.2422
Bhatt, R., Chopra, K., & Vashisht, R. (2019). Impact of integrated psycho-socio-economic support on treatment outcome in drug resistant tuberculosis – A retrospective cohort study. Indian Journal of Tuberculosis, 66(1), 105–110. https://doi.org/10.1016/j.ijtb.2018.05.020
CASP. (2018). CASP Randomised Controlled Trial Checklist.
Chaudhari, V. M. (2016). Studies on antimicrobial activity of antiseptic soaps and herbal soaps against selected human pathogens. Journal of Scientific and Innovative Research JSIR, 5(56), 201–204.
Checklist, C., & How, C. S. (2018). Critical Appraisal Skills Programme (2018). CASP (insert name of checklist i.e. Cohort Study) Checklist. [online] Available at: URL. Accessed: Date Accessed. 1–7.
De Bengoa Vallejo, R. B., Fernandez, D. S., Cervera, L. A., Aragón, L. M., Losa Iglesias, M. E., Collado Yurrita, L. R., & Lopez, D. L. (2018). Effectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub Cross-over trial. Medicine (United States), 97(42), 1–6. https://doi.org/10.1097/MD.0000000000012831
Huang, C. H., Chiu, C. H., Chen, I. W., Hung, S. Y., Lin, C. W., Hsu, B. R. S., & Huang, Y. Y. (2018). Antimicrobial resistance and outcomes of community-onset bacterial bloodstream infections in patients with type 2 diabetes. Journal of Global Antimicrobial Resistance, 15, 271–276. https://doi.org/10.1016/j.jgar.2018.08.008
Jeon, B., Choi, H. J., Kang, J. S., Tak, M. S., & Park, E. S. (2016). Comparison of five systems of classification of diabetic foot ulcers and predictive factors for amputation. 1–9. https://doi.org/10.1111/iwj.12642
Khan, Y., Khan, M. M., & Farooqui, M. R. (2017). Diabetic foot ulcers : a review of current management. 5(11), 4683–4689.
Liu, Z., Dumville, J. C., Hinchliffe, R. J., Cullum, N., Game, F., Stubbs, N., … Peinemann, F. (2018). Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus. Cochrane Database of Systematic Reviews, 2018(10). https://doi.org/10.1002/14651858.CD010318.pub3
Mathangi, T., Prabhakaran, P., Nadu, T., & Nadu, T. (2013). Prevalence of Bacteria Isolated from Type 2 Diabetic Foot Ulcers and the Antibiotic Susceptibility Pattern. International Journal of Current Microbiology and Applied Sciences, 2(10), 329–337.
Nurwahidah, Yusuf, S., & Tahir, T. (2018). Study Literatur Penggunaan Sabun Antiseptik Untuk Pencucian Luka Terhadap Penurunan Kolonisasi Bakteri Pada Pasien dengan Luka Kaki Diabetes. Jurnal Luka Indonesia, 4(2), 108–122.
OBI, C. N. (2014). antibacterial activities of medicated soaps on selected human pathogens.
Perim, M. C., Borges, J. da C., Celeste, S. R. C., Orsolin, E. de F., Mendes, R. R., Mendes, G. O., … Da Silva Pranchevicius, M. C. (2015). Aerobic bacterial profi le and antibiotic resistance in patients with diabetic foot infections. Revista Da Sociedade Brasileira de Medicina Tropical, 48(5), 546–554. https://doi.org/10.1590/0037-8682-0146-2015
Roukis, T. S. (2010). Bacterial skin contamination before and after surgical preparation of the foot, ankle, and lower leg in patients with diabetes and intact skin versus patients with diabetes and ulceration: A prospective controlled therapeutic study. Journal of Foot and Ankle Surgery, 49(4), 348–356. https://doi.org/10.1053/j.jfas.2010.04.022
Santos, R., Ruza, D., Cunha, E., Tavares, L., & Oliveira, M. (2019). Diabetic foot infections: Application of a nisin-biogel to complement the activity of conventional antibiotics and antiseptics against Staphylococcus aureus biofilms. PLoS ONE, 14(7), 1–16. https://doi.org/10.1371/journal.pone.0220000
Shahi, S. K., & Kumar, A. (2016). Isolation and genetic analysis of multidrug resistant bacteria from diabetic foot ulcers. Frontiers in Microbiology, 6(JAN), 1–13. https://doi.org/10.3389/fmicb.2015.01464
Skiles, M. P., Curtis, S. L., Angeles, G., Mullen, S., & Senik, T. (2018). Evaluating the impact of social support services on tuberculosis treatment default in Ukraine. PLoS ONE, 13(8), 1–13. https://doi.org/10.1371/journal.pone.0199513
Sørensen, M. L. B., Jansen, R. B., Wilbek Fabricius, T., Jørgensen, B., & Svendsen, O. L. (2019). Healing of Diabetic Foot Ulcers in Patients Treated at the Copenhagen Wound Healing Center in 1999/2000 and in 2011/2012. Journal of Diabetes Research, 2019. https://doi.org/10.1155/2019/6429575
Touzel, R. E., Sutton, J. M., & Wand, M. E. (2016). Establishment of a multi-species biofilm model to evaluate chlorhexidine efficacy. Journal of Hospital Infection, 92(2), 154–160. https://doi.org/10.1016/j.jhin.2015.09.013
Vali, L., Dashti, A. A., El-Shazly, S., & Jadaon, M. M. (2015). Klebsiella oxytoca with reduced sensitivity to chlorhexidine isolated from a diabetic foot ulcer. International Journal of Infectious Diseases, 34, 112–116. https://doi.org/10.1016/j.ijid.2015.03.021
Yu, J. J., Manus, M. B., Mueller, O., Windsor, S. C., Horvath, J. E., & Nunn, C. L. (2018). Antibacterial soap use impacts skin microbial communities in rural Madagascar. PLoS ONE, 13(8), 1–14. https://doi.org/10.1371/journal.pone.0199899
Yunding, M. (2019). efektifitas sabun antibakteri terhadap penurunan biofilem, koloni bakteri dan proses penyembuhan luka kaki diabetik: randomized clinical rtial.
Yusuf, S., Okuwa, M., Irwan, M., Rassa, S., Laitung, B., Thalib, A., … Sugama, J. (2016). Prevalence and Risk Factor of Diabetic Foot Ulcers in a Regional Hospital, Eastern Indonesia. Open Journal of Nursing, 06(01), 1–10. https://doi.org/10.4236/ojn.2016.61001
Published
2021-03-28
How to Cite
Tawil, S., Tahir, T., & Erika, K. (2021). Efek Penggunaan Chlorhexidine dalam Menurunkan Jumlah Bakteri pada Ulkus Kaki Dibetik: A Literature Review. Jurnal Keperawatan, 13(1), 191-198. https://doi.org/https://doi.org/10.32583/keperawatan.v13i1.1408
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Articles
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